Meet the Other Cannabinoids: CBG and CBC

Meet the Other CannabinoidsWhen you think of cannabinoids — the active constituents of cannabis — you probably think of THC and CBD. THC is the compound that leads to the “high” marijuana users experience. CBD is the non-intoxicating active ingredient in hemp oil products.

But there’s another pair of non-psychoactive cannabinoids worth getting to know: CBG, which stands for cannabigerol, and CBC, or cannabichromene. Research into CBG and CBC is in the preliminary stage, consisting of animal and test tube studies. But so far, the results are promising.

What does CBG do?
  • A 2015 animal study published in Neurotherapeutics hailed CBG as “extremely active as [a] neuroprotectant.”[i]
  •  A 2013 study of CBG’s effect on bowel health published in Biochemical Pharmacology concluded, “CBG attenuated murine [mouse] colitis,” and “CBG could be considered for clinical experimentation in IBD [Inflammatory Bowel Disease] patients.”[ii]A 2008 study published in the Journal of Natural Products found CBG “showed potent activity against a variety of methicillin [antibiotic] resistant Staphylococcus aureus (MRSA) strains.”[iii]
  • A 2016 study published in Experimental Dermatology found CBG “may have potential in the treatment of dry skin.”[iv]
 
What does CBC do?
  • The same dermatological study cited above predicted several cannabinoids, including CBC, “show promise to become highly efficient, novel anti-acne agents.”
  • A 2011 study in the British Journal of Pharmacology found CBC “caused analgesia [pain relief] by interacting with several target proteins.”[v]
  • A 2010 study in Pharmacology, Biochemistry, and Behavior found CBC exerted “antidepressant-like actions” in mice.[vi]
  • A 2013 study, published in Neurochemistry International, found CBC “raises the viability of NSCPs,” cells “which are an essential component of brain function.”[vii]
 
Decarboxylation Unlocks the Power

Before CBD and CBC can exert any effect, they must be decarboxylated. In simple terms, that means a carbon atom has to be removed in order to activate their powers. This can be achieved through heat and/or time (drying). For a CBD hemp oil to be effective, it must have gone through the decarboxylation process. (Barlean’s CBD products have.)

Full-Spectrum Activity Means More Benefits

Many people assume that all of hemp’s benefits are due to CBD. But as you’ve just learned, there are other compounds in the plant that have something to contribute. That’s why Barlean’s CBD hemp oils are full-spectrum extracts, capturing not just CBD but all the cannabinoids the hemp plant has to offer to create the beneficial entourage effect.

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References

[i] Valdeolivas S, et al. Neurotherapeutics. 2015 Jan;12(1):185-99.
[ii] Borrelli F, et al. Biochem Pharmacol. 2013 May 1;85(():1306-16.
[iii] Appendino G, et al. J Nat Prod. 2008 Aug;71(8):1427-30.
[iv] Oláh A, et al. Exp Dermatol. 2016 Sep;25(9):701-7.
[v] Malone S, et al. Br J Pharmacol. 2011 Feb;162(3);584-96.
[vi] El-Alfy AT, et al. Pharnacol Biochem Behav. 2010 Jun;95(4):434-42.
[vii] Shinjyo N, et al. Neurochemistry International. 2013 Nov;63(5):432-7.

 

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